Well, I'd lose my support network, so that's a big negative. If I did, I'd probably go for my primary fantasy setting, since I've fleshed it out way more and know how the magic works and Earth canonically exists, and I have set up the worldbuilding infrastructure so that if I were to get isekaid, it would have probably been because of something that will, one way or another, have significant potential advantages. Though, that might not be the best, considering one way, I'd inherit some powerful enemies, another means I'd spend a while in absolutely hellish torture for a while before fully isekaing, and another involves the clash of my soul and another's in a manner that could destroy large portions of my memory, my personality, or a mix of both. But otherwise! It's the most promising option.
Accidental world travellers automatically get all-speak in that setting, so no language barrier! It's my best bet because of that and because I could easily get magic, medium to high power magic, which would be enough to survive the wilderness (so long as it isn't a *particularly* inhospitable area), language issues wouldn't be a problem, and I have a path to great power. And depending on the development of the realm I land in, the manner in which one can awaken magic might not be fully discovered/understood, making me one of a rare class, meaning better treatment, and possibly, a significant lead in starting power relative to other mages. Not a bad start, though I may just stay in the wilderness and do my own thing, because politics and all the horrible stuff people do and have done all throughout history for all sorts of reasons. Wouldn't want to get on the bad side of all of that.
The question then becomes if my *mental* health could survive. As I mentioned, no support network, and I'd be without easy access to music or books. On the other hand, magic, and all the exploration thereof and possibilities unlocked by, and the disruption of my status quo might put me in a headstate that is more functional and stable. It would *also* be possible for me to return to Earth and my family. With caveats. It would require immense power and skill, *and* depending on the method, might result in me getting stuck on Earth again unable to use magic, in which case the entire thing was pointless (besides that I'd have gotten to use magic to adjust my appearance, though that would come with it's own downsides back on Earth).
All that to say- it's a gamble. Lose what I have to live for (which honestly isn't much), for a chance to maybe get some other stuff to live for. I'm gonna say no, unless I'm guaranteed a good start and a good romantic relationship not too far down the line.
And don't get it twisted, my other settings, unless one of the ones specifically designed as a semi-utopic place & circumstance for me to get away to in my head count, are worse.
Less specific fantasy system that I would be worse at navigating and doesn't come with free language is a no. Probably even if I got a variation where I DID get free language, and even was chosen as saintess by the goddess, or if I got the litrpg setting I made, even if I got to be the protagonist of that one.
One of two different but linked post-apocalyptic worlds, one with monsters and cults and cyberpunk magic, the other with killer robots (I haven't developed that side as much tbf) is a no.
Generic superhero setting that is like Earth, but I lose my family by virtue of being there, and the evil people have superpowers? A no, especially if I'm not guaranteed my choice power set, or if I DO get that power set but ALSO have to experience that character's backstory.
Cyber punk but with my take on anomalies? Hard no.
