Aren't the most western harem novel like this?
At least, as long as there is a male main character, it is focused on his relationship with the girls / women, and all women are primarily interested in him (though some are rarely interested in each other, it is not the main focus on the book)
In case of anime (manga, light novel) they have this tendency to go one step forward, two steps back, so you could question who is interested in who, though even there, as long as there is a male main character he is the (supposedly) primary target of affection.
In case it is female main character, then all bets are off, and it would be likely yuri rather than not.